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KMID : 0882420120820010115
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Korean Journal of Medicine
2012 Volume.82 No. 1 p.115 ~ p.118
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Fatal Hypersensitivity Reactions Induced by Re-Administration of Rifampin in an Immunocompetent Patient with Tuberculous Lymphadenopathy
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Kim Ye-Ji
Lim Sun-Young
Bae Song-I
Ahn Jae-Hee
Chang Won-Gin
Sohn Jang-Wook
Kim Min-Ja
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Abstract
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A 44-year-old patient who had been diagnosed with tuberculous lymphadenopathy came to our hospital with a rash. He began to take antituberculous medications, but the next day, a rash appeared and persisted for one week. When he came to the hospital, he had already stopped the medication by his own decision. We stopped all drugs and reintroduced one drug at a time. After re-administration of rifampin, anaphylactic shock and subsequent acute renal failure and rhabdomyolysis occurred. Intensive care was performed, but the patient died 60 h after the first hypersensitive reaction that occurred due to rifampin. Anaphylaxis and subsequent rhabdomyolysis induced by rifampin is an extremely rare event. It is necessary to initially prescribe low dose rifampin in cases of re-administration.
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KEYWORD
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Anaphylaxis, Rhabdomyolysis, Rifampin
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